Why does avastin cause proteinuria

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If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and Permissions. Onodera, R. Severe proteinuria during the administration of bevacizumab plus mFOLFOX6 in a colorectal cancer patient after kidney transplantation: a case report.

J Pharm Health Care Sci 6, 19 Download citation. Received : 20 March Accepted : 14 August Published : 04 September Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Case presentation The patient was a year-old man with a history of diabetes and hypertension. Conclusions In this case, BEV administration caused severe proteinuria without affecting blood levels of tacrolimus. Background Kidney transplant, commonly performed for end-stage renal disease, is an alternative to dialysis.

Case presentation Patient background The patient was a year-old man with a history of diabetes and hypertension. Full size image. Discussion In this case, the patient who had been taking an immunosuppressant for a long time after kidney transplantation developed severe proteinuria on BEV administration.

Availability of data and materials All data generated or analyzed during this study are included in this published article. References 1. Article Google Scholar 2. Article Google Scholar 3.

Article Google Scholar 4. Article Google Scholar PubMed Google Scholar Google Scholar Article Google Scholar Download references. Acknowledgments Not applicable. Funding No funding was received. View author publications. Ethics declarations Ethics approval and consent to participate Not applicable. Consent for publication The patient consented for publication of this report.

Competing interests The authors declare that they have no competing interests. About this article. Cite this article Onodera, R. Copy to clipboard. Contact us Submission enquiries: Access here and click Contact Us General enquiries: info biomedcentral. Proteinuria is assessed and graded based on urine dipstick testing or hour urine collection results Table 1.

Nephrotic syndrome is a clinical complex characterized by 14 The presence of proteinuria during bevacizumab therapy is statistically associated with hypertension, although a causative relationship has not yet been established.

No temporal relationship was found in an observational study in which it was noted that half the patients developed hypertension first and the other half developed proteinuria. Assessment Tools Table 1. Common Terminology Criteria for Adverse Events v4. Description Excessive protein in the urine predominately albumin, but also globulin. Patient Care Gobel 10 reviewed nursing considerations for bevacizumab use, including information on assessment and management of proteinuria.

Patients on bevacizumab therapy should undergo serial monitoring of urine protein levels by dipstick or hour urine collection because hydration and nutrition affect urine density and volume. Comorbidities that can contribute to proteinuria, such as hypertension and diabetes, should be considered. The risk of continuation or temporary suspension of bevacizumab in patients with moderate to severe proteinuria is unknown.

There are no specific recommendations or guidelines for management of proteinuria. Other Oncology. TV sites:. This could lead to a wide range of new treatments that are less onerous for kidney The study signifies a significant milestone in the Print Email Share. Just a Game? Living Well. View all the latest top news in the environmental sciences, or browse the topics below:. Bryan Becker, president of the National Kidney Foundation, who is not affiliated with the group that carried out the current study.

However, some doctors said the incidence of proteinuria with the treatment is not a cause for alarm. Otis Brawley, the American Cancer Society's chief medical and scientific officer, who likewise had no involvement with this research. It also doesn't concern year-old Julie Del Giorno, a Pennsylvania woman who took Avastin to treat her ovarian cancer as part of a clinical trial last year. After reading about the side effects of Avastin and consulting with her doctor, she decided to give it a try.

Still, the researchers and other medical experts agree that the results of the study indicate the importance of keeping a close eye on kidney function.